We offer non-toxic silica probes in the nanometer scale range for cellular and chemical research. Such nanoobjects have been widely used in experimental studies of intracellular
diffusion processes, sorption/desorption kinetics of medical drugs, and intracellular drug transport processes. Excellent fluorescent properties make our probes suitable for biological imaging.
The prices of our products are independent of the type of surface ligand and the fluorescent dye, and vary solely on the size of the nanoobjects.
The offered silica nanoparticles can be fluorescent or non-fluorescent. We offer nanoparticles incorporated with a fluorescent dye (Rhodamine B or Fluorescein) or made of pure silica.
For our customers’ convenience each of our products is available in three different forms – in the solid state, as well as in aqueous or ethanol solution. We hope this will extend the applicability of our products.
Each of our nanoparticular probes can be surface coated in one of four offered ligands, depending on the research targets.
We offer the following ligands:
- PEG ligand – recommended in case of intracellular experiments. PEG coated nanoparticles are known to exhibit good stability in crowded biological environments, such as the cellule. Aggregation tendency is significantly reduced.
- R-NH2 – Amine terminated ligand –a short hydrocarbon chain (3 carbon atoms) with a reactive primary amine group in the terminal position. The presence of terminal amine groups renders these nanoparticles soluble in polar environments. Protonation of the nitrogen atom in acidic conditions affords partial positive charge of the nanoparticles’ surface. Highly reactive nature of the amine functional group allows for chemical attachment of a wide variety of chemical molecules.
- R-COOH – carboxyl terminated ligand – a 10 carbon atom hydrocarbon chain with a reactive carboxyl acid group in the terminal position. Deprotonation of the carboxyl group in basic conditions affords partial negative charge of the nanoparticles’ surface, significantly increasing their solubility in polar solutions. Presence of the carboxyl group in an easily accessible position allows for maintenance of typical reactivity of this functional group.
- C8 – octyl ligand – 8 carbon atom hydrocarbon chain. Hydrophobic nature of the ligand renders nanoparticles soluble in nonpolar solvents. Lack of terminal reactive groups makes them resistant to most chemical reagents.