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Our focus is turned towards non-toxic silica probes in the nanometer scale range for cellular and chemical research. Such nanoobjects have been widely used in experimental studies of intracellular diffusion processes, sorption/desorption kinetics of medical drugs, and intracellular drug transport processes. Excellent fluorescent properties make our probes suitable for biological imaging.

Our nanoparticles are surface coated with one of the following ligands:

• PEG ligand – recommended in case of intracellular experiments. PEG coated nanoparticles are known to exhibit good stability in crowded biological environments, such as the cellule. Aggregation tendency is significantly reduced.
• R-NH2 – Amine terminated ligand –a short hydrocarbon chain (3 carbon atoms) with a reactive primary amine group in the terminal position. The presence of terminal amine groups renders these nanoparticles soluble in polar environments. Protonation of the nitrogen atom in acidic conditions affords partial positive charge of the nanoparticles’ surface. Highly reactive nature of the amine functional group allows for chemical attachment of a wide variety of chemical molecules.

For our customers’ convenience our products are available in two different forms –aqueous or ethanol solutions.

The offered silica nanoparticles can be fluorescent, with Rhodamine B incorporated into the structure of the core or non-fluorescent, made of pure silica. The prices of our products are independent of the type of surface ligand, and vary solely on the size of the nanoobjects.

For customers in need of a more individual approach we offer the possibility of synthesizing nanoprobes tailored to the specific needs, including other probe sizes, fluorescent dyes, surface ligands. For more details about the possibility of synthesis of custom-made nanoparticles please contact us!

Publications with the use of Siliquan Nanoprobes

Determination of oligomerization state of Drp1 protein in living cells at nanomolar concentrations

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